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References from Detail Aid: Full papers & abstracts

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1 Carmina E, Lobo RA, Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004 Sep;82(3):661- 5.


2 De Ugarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril 2005;83:1454–60.


3 Dusková M et al. What may be the markers of the male equivalent of polycystic ovary syndrome? Physiol Res. 2004;53(3):287-94.


4 Sam S, Dunaif A et al, Metabolic phenotype in the brothers of women with PCOS. Diabetes Care.
2008 Jun;31(6):1237-41


5 Coviello AD, Sam S, Legro RS, Dunaif A, High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity. J Clin Endocrinol Metab. 2009 Nov;94(11):4361-6


6 Kennington AS et al. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med. 1990 Aug 9;323(6):373-8.


7 Ikezaki, Hiroaki et al. The utility of urinary myo-inositol as a marker of glucose intolerance. Diabetes Res Clin Pract. 2014 Jan;103(1):88-96


8 Hong JH et al. Urinary chiro- and myo-inositol levels as a biological marker for type 2 diabetes mellitus. Dis Markers. 2012;33(4):193-9. doi: 10.3233/DMA-2012-0925.


9 Daughaday WH, Larner J, The renal excretion of inositol in normal and diabetic human beings. J Clin Invest.
1954 Mar;33(3):326-32


10 Garg D, Tal R. Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol. 2016 Epub


11 Chiu TT et al, Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF:
relationship with oocyte quality. Hum Reprod. 2002 Jun;17(6):1591-6.


12 Calogero AE et al, Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study. Andrology. 2015 May;3(3):491-5


13 Diamanti-Kandarakis E, Dunaif A, Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications. Endocrine Reviews 33:981–1030, 2012


14 G. Carlomagno, V. Unfer, Inositol safety: clinical evidence. Eur Rev Med & Pharm Sci 2011: 15: 931-6


15 Zacchè et al, Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocr Aug 2009; 25(8): 508-513

16 Minozzi M, Costantino D et al, The effect of a combination therapy with myo-inositol and a combined OCP
versus a combined OCP alone on metabolic, endocrine, and clinical parameters in PCOS. Gynecol Endocrinol. 2011 Nov;27(11):920-4


17 Capasso I, Esposito E et al, Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo controlled trial. Trials 2013, 14:273


18 Santamaria A et al, One year effects of myo-inositol in postmenopausal women with metabolic syndrome. Climacteric 2012; 15: 490-495


19 Kamenov Z et al, Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol. 2015 Feb;31(2):131-5.


20 Brusco GF &, Mariani M, Inositol: effects on oocyte quality in patients undergoing ICSI. An open study. Eur Rev Med Pharmacol Sci. 2013 Nov;17(22):3095-102.


21 Artini P, Di Berardino O et al, Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome – A randomised study. Gynec Endoc, 2013; 29(4):375- 379


22 Caprio F, D’Eufemia MD et al, Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial. J Ovarian Res. 2015 Jun 12;8:37.


23 Lisi F, Carfagna P et al, Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reprod Biol Endocrinol. 2012 Jul 23;10:52.


24 Palomba S et al, Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial. Fertil Steril. 2011 Nov;96(5):1128-33.


25 Rubino P, Palini S et al, Improving fertilization rate in ICSI cycles by adding myoinositol to the semen
preparation procedures: a prospective,
bicentric,randomized  trial on sibling oocytes. J Assist Reprod Genet. 2015 Mar;32(3):387-94.


26 Palmieri M, Papale P et al, In Vitro Antioxidant Treatment of Semen Samples in Assisted Reproductive Technology: Effects of Myo-Inositol on Nemaspermic Parameters. Int J Endocrinol. 2016;2016:2839041


27 Gulino FA, Leonardi E et al, Effect of treatment with myo-inositol on semen parameters of patients undergoing an IVF cycle: in vivo study. Gynecol Endocrinol. 2016;32(1):65-8.


28 Calogero AE et al, Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study. Andrology. 2015


29 O’Sullivan EP, G. Avalos G et al, Atlantic Diabetes in Pregnancy (DIP): the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria Diabetologia (2011) 54:1670–1675




31 D’Anna R et al, Myo-Inositol Supplementation and Onset of Gestational Diabetes Mellitus in Pregnant Women With a Family History of Type 2 Diabetes - a prospective, randomized, placebo-controlled study. Diabetes Care, Vol 36, April 2013: 854-857

32 Santamaria A, Di Benedetto A et al, Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. J Matern Fetal Neonatal Med. 2016 Oct;29(19):3234-7.


33 D’Anna R, Di Benedetto A et al, Myo-inositol Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women: A Randomized Controlled Trial. Obstet Gynecol. 2015 Aug;126(2):310-5


34 Matarrelli B, Vitacolonna E et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med. 2013 Jul;26(10):967-72


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