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Improves male fertility
“MI is a safe supplement able to increase sperm parameters in patients with idiopathic infertility”
In vitro use of myo-inositol on frozen and fresh semen samples has been shown to improve sperm motility, fertilisation rate and the percentage of Grade A embryos at day 3. It is also very well tolerated and begs the question of whether its use in vivo could replicate those benefits. The active ingredient is often added to semen samples that are to be used for IVF or ICSI, where it promotes motility and activity levels. Can similar benefits can be achieved by taking Replenitol on a daily basis? The short answer is "yes".
General population studies and studies of male relatives of women with PCOS have shown that a similar proportion of men share the altered biochemical profile typical of PCOS as women. MI depletion in men can give rise to insulin resistance and resultant hyperinsulinaemia which, in turn, affects other hormones. It also impacts negatively on fertility rates as MI is normally highly concentrated in epididymal ﬂuid. Treatment with
Replenitol can supplement the deficiency and improve fertility. The protocol used in this large, randomised study was 2g taken twice daily for 3 months - this time frame is important because the maturation time for sperm (spermatogenesis) is estimated to take 74-120 days.
Oral administration significantly improves semen parameters both in patients with OA and in normal fertile men
From the results above, you can see that the two "female sex hormones" luteinising hormone (LH) and follicle-stimulating hormone (FSH) are reduced by over one third and the "male sex hormone" testosterone increases by a fifth, normalising the male hormonal profile. There are direct effects on the sperm too: concentration, sperm count, progressive motility and acrosome activation (required for the sperm to fertilise the egg) are all significantly improved, boosting the chances of achieving a successful pregnancy.
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